Diethyl phosphorochloridate
Diethyl phosphorochloridate - Names and Identifiers
| Name | Diethyl chlorophosphate |
| Synonyms | Diethyl chlorophosphate Diethoxy chlorophosphate diethyl phosphoryl chloride Diethyl phosphoric chloride Diethyl phosphorochloridate Chlorophosphonic acid diethyl Chloridophosphoric acid diethyl chlorophosphoric acid diethyl ester Chlorophosphonic acid diethyl ester Chloridophosphoric acid diethyl ester Phosphoric acid chloride diethyl ester Phosphorochloridic acid diethyl ester Chlorophosphonic acid O,O-diethyl ester |
| CAS | 814-49-3 |
| EINECS | 212-396-4 |
| InChI | InChI=1/C4H10ClO3P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3 |
| InChIKey | LGTLXDJOAJDFLR-UHFFFAOYSA-N |
Diethyl phosphorochloridate - Physico-chemical Properties
| Molecular Formula | C4H10ClO3P |
| Molar Mass | 172.55 |
| Density | 1.194g/mLat 25°C(lit.) |
| Melting Point | 95-96 °C |
| Boling Point | 60°C2mm Hg(lit.) |
| Flash Point | 142°F |
| Water Solubility | Soluble in alcohol and chloroform. Slightly soluble in water. |
| Vapor Presure | 0.1 mm Hg ( 25 °C) |
| Vapor Density | 5.94 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to light yellow |
| BRN | 471433 |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.416(lit.) |
| Physical and Chemical Properties | This product is pure oily liquid, B. P. 86 ℃/1.60kPa,n25D 1.4162, relative density 1.20, soluble in organic solvents such as benzene. |
| Use | Used as a pharmaceutical Intermediate |
Diethyl phosphorochloridate - Reference Information
| LogP | 0.61 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | O,O-diethyl phosphoryl chloride is the insecticide ethyl sulphoxide (cotton phosphorus), Rice cotton phosphorus (rice phosphorus) of the intermediates. intermediates in organic synthesis. used as pharmaceutical intermediates |
| production method | diethyl phosphite was dissolved in carbon tetrachloride, cooled to 0 °c, triethylamine was added under stirring, and reacted for 15min. The reaction was allowed to warm to room temperature and stirred for a further 3H. The filtrate was filtered, and the filtrate was reduced to 2.67kPa at room temperature, and the low boiling material was distilled off, followed by distillation under reduced pressure to collect a fraction of 58-60 ° C. (0.266kPa) to obtain diethyl chlorophosphate. The yield was 81%. O,O-diethylphosphoryl chloride is synthesized by two methods: One is that ethanol is esterified with phosphorus trichloride to form diethyl phosphite, and then chlorinated with chlorine; the other is a one-step synthesis with ethanol and phosphorus oxychloride. The first method is generally used. Add 70g of industrial alcohol into a 500mL three-mouth bottle equipped with a stirrer, a thermometer and a dropping funnel, cool to below 5 ℃ in an ice-salt bath, start the vacuum Mercury, and make the vacuum degree reach 80 kPa, 72g of phosphorus trichloride was added dropwise under the liquid surface. After completion of the dropwise addition, chlorine gas was chlorinated immediately, and the vacuum degree could be appropriately reduced. About 0.5h after passing chlorine gas, the reaction liquid changes from colorless to yellow-green, and the reaction temperature decreases obviously, which is the end point of the reaction. The chlorine gas supply is stopped, the vacuum degree is increased, the temperature is raised slowly, and dry air is introduced to remove excess chlorine gas and hydrogen chloride generated by the reaction by bubbling, that is, the product is 80-90g, the yield and content are above 85%. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:12
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